Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation By similarity.Ma Z., Nat. Genet. 28:220-221(2001).Mercher T., Proc. Natl. Acad. Sci. U.S.A. 98:5776-5779(2001).Nagase T., DNA Res. 7:65-73(2000).
应用类型
WB
免疫原
Synthesized peptide derived from N-terminal of human MKL1.
