DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway By similarity. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.Favre C., Genes Immun. 4:40-45(2003).Cai D., J. Biol. Chem. 278:25323-25330(2003).Loftus B.J., Genomics 60:295-308(1999).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human DOK4.
