Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.Miura Y., J. Biol. Chem. 270:26840-26848(1995).Morinaga T., Mol. Cell. Biol. 11:6041-6049(1991).Martin J., Nature 432:988-994(2004).
应用类型
IHC
免疫原
Synthesized peptide derived from internal of human ZFHX3.
