Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES By similarity.Nagase T., DNA Res. 6:337-345(1999).Humphray S.J., Nature 429:369-374(2004).Stifani S., Nat. Genet. 2:119-127(1992).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human TLE4.
