Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES By similarity.Stifani S., Nat. Genet. 2:119-127(1992).Grimwood J., Nature 428:529-535(2004).Grbavec D., Eur. J. Biochem. 258:339-349(1998).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human TLE2.
