Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.Johnson K.W., J. Biol. Chem. 266:3402-3407(1991).Hanes J.J., J. Mol. Biol. 244:665-672(1994).Olsen J.V., Cell 127:635-648(2006).
应用类型
WB,ICC
免疫原
Synthesized peptide derived from internal of human CLK1.
