Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.Chuang T.T., J. Biol. Chem. 267:6886-6892(1992).Penn R.B., J. Biol. Chem. 269:14924-14930(1994).Fushman D., J. Biol. Chem. 273:2835-2843(1998).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human ARBK1.
