Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (). Recruits histone deacetylases and DNA methyltransferases.Hendrich B., Mol. Cell. Biol. 18:6538-6547(1998).Grimwood J., Nature 428:529-535(2004).Tatematsu K., Genes Cells 5:677-688(2000).
应用类型
WB
免疫原
Synthesized peptide derived from C-terminal of human MBD3.
