Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.Yao Z., J. Biol. Chem. 274:2118-2125(1999).Wright J.H., Mol. Cell. Biol. 23:2068-2082(2003).Ishikawa K., DNA Res. 5:169-176(1998).
应用类型
WB,ICC
免疫原
Synthesized peptide derived from internal of human MEKKK 4.
