Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.Horrevoets A.J.G., Blood 93:3418-3431(1999).Kumar D., J. Biol. Chem. 275:2973-2978(2000).You Z., J. Biol. Chem. 276:26398-26404(2001).
应用类型
WB,IHC,ICC
免疫原
Synthesized peptide derived from internal of human TFIP8.
