Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.Yuan C.-X., Proc. Natl. Acad. Sci. U.S.A. 95:7939-7944(1998).Rachez C., Genes Dev. 12:1787-1800(1998).Nagase T., DNA Res. 2:167-174(1995).
应用类型
WB,ICC
免疫原
Synthesized peptide derived from internal of human MED24.
