Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.Chicheportiche Y., J. Biol. Chem. 272:32401-32410(1997).Marsters S.A., Curr. Biol. 8:525-528(1998).Clark H.F., Genome Res. 13:2265-2270(2003).
应用类型
WB,IHC,ICC
免疫原
Synthesized peptide derived from internal of human TNF12.
