Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.Susanne Frese, J. Biol. Chem., Jun 2006; 281: 18236 - 18245. Friedhelm Bladt, Mol. Cell. Biol., Jul 2003; 23: 4586 - 4597. Stephan J. Kempiak, J. Biol. Chem., Feb 2005; 280: 5836 - 5842.Min Chen, Mol. Cell. Biol., Nov 2000; 20: 7867 - 7880.
应用类型
IHC
免疫原
Synthesized peptide derived from C-terminal of human NCK2.
