Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Winkelmann J.C., Blood 76:24-30(1990) [PubMed: 2163695].Jones S.S.,Blood 76:31-35(1990) [PubMed: 2163696].Noguchi C.T., Blood 78:2548-2556(1991) [PubMed: 1668606].
应用类型
WB
免疫原
Synthesized peptide derived from Internal of human Epo-R.
