May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.Fukunaga R., EMBO J. 16:1921-1933(1997).Knauf U., Mol. Cell. Biol. 21:5500-5511(2001).O'Loghlen A., Exp. Cell Res. 299:343-355(2004).
应用类型
WB
免疫原
Synthesized non-phosphopeptide derived from human Mnk1 around the phosphorylation site of threonine 385 (L-P-T(p)-P-Q).
