Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.Goshima Y., Nature 376:509-514(1995).Hamajima N., Gene 180:157-163(1996).Kitamura K., DNA Res. 6:291-297(1999).
应用类型
WB,IHC
免疫原
Synthesized non-phosphopeptide derived from human CRMP-2 around the phosphorylation site of threonine 509 (S-V-T(p)-P-K).
