Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.Stephens R.M., Mol. Cell. Biol. 12:3733-3742(1992).Hillier L.W., Nature 424:157-164(2003).Eychene A., Oncogene 7:1657-1660(1992).
应用类型
WB
免疫原
Synthesized non-phosphopeptide derived from human B-Raf around the phosphorylation site of threonine 735 (P-K-T(p)-P-I).
