Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.Saunders W.S., J. Cell Sci. 104:573-582(1993).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ye Q., J. Biol. Chem. 271:14653-14656(1996).
应用类型
WB,IHC
免疫原
Synthesized non-phosphopeptide derived from human HP1 alpha around the phosphorylation site of serine 92 (R-K-S(p)-N-F).
