Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.Geller D.A., Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993).Sherman P.A., Biochemistry 32:11600-11605(1993).Charles I.G., Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993)
应用类型
WB
免疫原
Synthesized non-phosphopeptide derived from human iNOS around the phosphorylation site of tyrosine 151 (Q-Y-Y(p)-G-S).
