Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.The MGC Project Team; Genome Res. 14:2121-2127(2004).Xu H., J. Biol. Chem. 273:17987-17990(1998).Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
应用类型
WB
免疫原
Synthesized non-phosphopeptide derived from human FRS2 around the phosphorylation site of tyrosine 196 (H-T-Y(p)-V-N).
