Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.Mills G.B., J. Biol. Chem. 267:16000-16006(1992).Ota T., Nat. Genet. 36:40-45(2004).Mungall A.J., Nature 425:805-811(2003)
应用类型
WB,IHC
免疫原
Synthesized non-phosphopeptide derived from human TTK around the phosphorylation site of threonine 676 (D-T-T(p)-S-V).
