Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.Hannigan G.E.,Nature 379:91-96(1996).Janji B.,Oncogene 19:3069-3077(2000).Tadic B.,Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
应用类型
WB,IHC
免疫原
Synthesized non-phosphopeptide derived from human ILK around the phosphorylation site of serine 246 (I-F-S(p)-H-P).
