Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.Stephens R.M., Mol. Cell. Biol. 12:3733-3742(1992).Albert S., Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.Hillier L.W., Nature 424:157-164(2003)
应用类型
WB,IHC
免疫原
Synthesized non-phosphopeptide derived from human B-RAF around the phosphorylation site of serine 446 (R-D-S(p)-S-D).
