Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.Galaktionov K.I.,Cell 67:1181-1194(1991).The MGC Project Team;Genome Res. 14:2121-2127(2004).Wegener S., Eur. J. Cell Biol. 79:810-815(2000).
应用类型
WB
免疫原
Synthesized non-phosphopeptide derived from human CDC25A around the phosphorylation site of serine 178 (Q-N-S(p)-A-P).
