Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.Puig B, et al. (2005) Acta Neuropathol (Berl). 110(3):261-268.DeGiorgis JA, et al. (2005) J Proteome Res. 4(2): 306-315.Alonso Adel C, et al. (2004) J Biol Chem. 279(33): 34873-34881.
应用类型
WB
免疫原
Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of Serine 396.
