Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.Mattioli I, et al. (2004)J Immunol; 172(10): 6336-44.Courtois G, et al. (2003)J Clin Invest; 112(7): 1108-15.Nair A, et al. (2003) Oncogene; 22(1): 50-8.Fan C, et al. (2002)J Cell Sci; 115(Pt 24): 4843-53.Schubert SY, et al. (2002)FASEB J; 16(14): 193
应用类型
WB,IHC
免疫原
Synthesized non-phosphopeptide derived from human IκB-α around the phosphorylation site of Serine 32/36.
