May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity.Araki E., Diabetes 42:1041-1054(1993).Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992).The MGC Project Team; Genome Res. 14:2121-2127(2004)
应用类型
WB,IHC,ICC
免疫原
Synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 312 (A-T-S(p)-P-A).
