Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' By similarity. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.Nakai A., Mol. Endocrinol. 4:1438-1443(1990).Chang C., J. Steroid Biochem. 34:391-395(1989).The MGC Project Team; Genome Res. 14:2121-2127(2004).
应用类型
WB,IHC
免疫原
Synthesized non-phosphopeptide derived from human Nuclear Receptor NR4A1 around the phosphorylation site of serine 351 (L-P-S(p)-K-P).
