PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
应用类型
IHC
免疫原
Peptide sequence around aa.465~469(L-Y-E-E-Y) derived from Human PI3 Kinase p85/p55.
