This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
应用类型
IHC
免疫原
Peptide sequence around aa.140~144 (D-L-S-S-D) derived from Human CREB.
