DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
应用类型
WB,IHC
免疫原
Peptide sequence around aa.360~364 (P-I-Y-D-E) derived from Human p62Dok.
