May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
应用类型
WB,ICC
免疫原
Peptide sequence around aa.637~641 (P-K-S-V-S) derived from Human IRS-1.
