Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.
应用类型
WB
免疫原
Peptide sequence around aa. 395~399 (D-D-Y-A-E) derived from Human FAK.
