Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.
应用类型
WB,IHC
免疫原
Peptide sequence around aa.8~12 (N-G-S-P-S) derived from Human p27Kip1.
