May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
应用类型
WB
免疫原
Peptide sequence around aa.143~147 (R-Q-T-S-M) derived from Human p21Cip1.
