ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
应用类型
WB
免疫原
Peptide sequence around aa. 510~514 (K-K-Y-R-L) derived from Human ICAM-1.
