Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
应用类型
WB
免疫原
Peptide sequence around phosphorylation site of Serine 776n(R-W-S(p)-A-P) derived from Human Ataxin 1.
