This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. Mackenzie KF, et al. (2013) J Immunol 190, 565-77 Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26 Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92
应用类型
WB
免疫原
Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .
