Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis.Hammond S.M., J. Biol. Chem. 272:3860-3868(1997) [PubMed: 9013646]Steed P.M., FASEB J. 12:1309-1317(1998) [PubMed: 9761774]Lopez I., J. Biol. Chem. 273:12846-12852(1998) [PubMed: 9582313]
应用类型
WB
免疫原
Peptide sequence around phosphorylation site of threonine 147(R-H-T(p)-F-R) derived from Human PLD1.
