The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.Kamine J., Virology 216:357-366(1996)Sheridan A.M., Mol. Cell. Biol. 21:4470-4481(2001)Legube G., Gene 310:161-168(2003)
应用类型
IHC
免疫原
Peptide sequence around phosphorylation site of Serine 90(P-G-S(p)-P-E) derived from Human Tip60.
