TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Aplan P.D., Mol. Cell. Biol. 10:6426-6435(1990)Gregory S.G., Nature 441:315-321(2006)Chen Q., J. Exp. Med. 172:1403-1408(1990)
应用类型
WB
免疫原
Peptide sequence around phosphorylation site of Serine 122(Q-L-S(p)-P-P) derived from Human TAL-1.
