Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.Steed P.M., FASEB J. 12:1309-1317(1998)Lopez I., J. Biol. Chem. 273:12846-12852(1998)Divecha N., EMBO J. 19:5440-5449(2000)
应用类型
WB,IHC
免疫原
Peptide sequence around phosphorylation site of tyrosine 169(E-N-Y(p)-L-N) derived from Human PLD2.
