This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.Sirotkin H., Genomics 42:245-251(1997)Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004)The MGC Project Team; Genome Res. 14:2121-2127(2004)
应用类型
IHC
免疫原
Peptide sequence around phosphorylation site of tyrosine 217 (K-K-N-Y(p)-V) derived from Human Claudin 5.
