Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.Shibuya M., Oncogene 5:519-524(1990)Kendall R.L., Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709(1993)The MGC Project Team; Genome Res. 14:2121-2127(2004).
应用类型
IHC
免疫原
Peptide sequence around phosphorylation site of tyrosine 1048 (D-I-Y(p)-K-N) derived from Human VEGFR1.
