Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989)Shelton D.L., J. Neurosci. 15:477-491(1995)The MGC Project Team, Genome Res. 14:2121-2127(2004)
应用类型
IHC
免疫原
Peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y(p)-A-I) derived from Human Trk A.
