The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.Durkin J.T., Biochemistry 43:16348-16355(2004)The MGC Project Team; Genome Res. 14:2121-2127(2004)Dorow D.S.,Nature 446:153-158(2007).
应用类型
IHC
免疫原
Peptide sequence around phosphorylation site of threonine 312/266(A-G-T(p)-Y-A) derived from Human MLK1/2.
