Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.Hannigan G.E., Nature 379:91-96(1996)Janji B., Oncogene 19:3069-3077(2000)Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
应用类型
IHC
免疫原
Peptide sequence around phosphorylation site of Serine 246(I-F-S(p)-H-P) derived from Human ILK.
