This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.Ullrich A., EMBO J. 5:2503-2512(1986)Abbot A.M., J. Biol. Chem. 267:10759-10763(1992)The MGC Project Team;Genome Res. 14:2121-2127(2004)
应用类型
IHC
免疫原
Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R .
