Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).Ellis N.A., Cell 83:655-666(1995)Karow J.K., J. Biol. Chem. 272:30611-30614(1997)Pichierri P., EMBO J. 23:3154-3163(2004)
应用类型
WB,IHC
免疫原
Peptide sequence around phosphorylation site of threonine 99 (Q-E-T(p)-Q-R) derived from Human Bloom Syndrome.
