Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Francesca Andriani. J Natl Cancer Inst, Sep 2001; 93: 1314 - 1324. H Martinez-Valdez. J. Exp. Med., Mar 1996; 183: 971. Joslyn K. Brunelle. J. Biol. Chem., Feb 2004; 279: 4305 - 4312
应用类型
ICC
免疫原
Peptide sequence around phosphorylation site of threonine167 (P-G-T(p)-P-T) derived from Human Bax.
